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Regular stress reduction practices, whether meditation, deep breathing, time in nature, or social connection, support the metabolic environment that produces the best GLP-1 results

Medical oversight is crucial, particularly to identify infrequent but severe side effects such as pancreatitis or allergic reactions

The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)

Plant polysaccharides also can inhibit upstream transcriptional factor Nrf2 expression, to suppress its downstream target proteins including HO-1, SLC7A11, and GPX4, ultimately leading to cancer cell death (Wang et al., 2024b)