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Pioglitazone was not mutagenic in a battery of genetic toxicology studies, including the Ames bacterial assay, a mammalian cell forward gene mutation assay (CHO/HPRT and AS52/XPRT), an in vitro cytogenetics assay using CHL cells, an unscheduled DNA synthesis assay and an in vivo micronucleus assay
The BA is a key preservative that prevents microorganisms from growing once the vials rubber stopper has been pierced (known as multi-dosing)
We also included patients with at least one claim with a diagnosis of obesity (ICD-10 CM: E66.9, E66.09, E66.1, E66.8, and Z68.3) before the index date and continuous medical and pharmacy benefits for 12 months pre-index date
If you take Topiramate during pregnancy, your baby has a higher risk for birth defects called cleft lip and cleft palate
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