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In parallel, the expression of oncogenes, such as p53, CDH1/E-cadherin, and adenomatous polyposis coli (APC), is significantly downregulated (Meli et al., 2019)

NAC has been used clinically for decades as an FDA-approved drug for acetaminophen overdose (where it replenishes hepatic glutathione) and as a mucolytic agent [18]

Further, controlled clinical studies simulating NSW provide causal evidence that melatonin secretion diminishes rapidly upon night work exposure and remains suppressed with continued circadian disruption 183

this short peptide backbone and specific residue composition contribute to structural stability in experimental environments