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GLP-1 medications deliver substantially greater weight loss: semaglutide trials showed 1015% body weight reduction over 68 weeks, and tirzepatide (a dual GLP-1/GIP agonist) demonstrated 20%+ reductions in some cohorts
The pricing framework reflects: Manufacturing complexity (highest in the Durham Peptides catalog due to retatrutide's structural features) Quality verification investments (Janoshik third-party testing per batch) Canadian-domestic supply chain (same-day Ontario shipping, no customs uncertainty) Research-use-only regulatory framework Pricing in the research peptide market evolves over time as manufacturing efficiency improves, competition develops, and supply chains mature
So, semaglutide dosing and titration may step back when gaps happen
On GLP-1, power declined more than weight
