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With both medications, symptoms occurred most often while the dose was being increased and generally became less frequent over time

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BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protective protein found in gastric juice

Unexpectedly, epalrestat treatment alone markedly exaggerated the disease severity in adjuvant induced arthritic (AIA) rats with elevated Th17 cell proportion and increased inflammatory markers, probably resulting from the increased levels of 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA)