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Given the potential effects on angiogenesis and tissue growth, patients should be monitored for any signs of abnormal tissue proliferation or changes that could indicate malignant transformation

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22 Based on the favorable bioavailability of the amide, N-acetylcysteine amide (NACA), over the acid, NAC, 23 and likely its methyl ester, 24 the pursuit of NACA therapy for treatment of HCCAA is warranted

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