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A study reported by Barreiro [20] showed that protein carbonyl is produced by Fenton reaction of oxidants with threonine, proline, arginine, and lysine residues of the protein side chains

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Patients with Hepatic Impairment In adult patients with mild, moderate, and severe hepatic impairment according to the Child-Pugh classification, AUC of empagliflozin increased by approximately 23%, 47%, and 75%, and Cmax increased by approximately 4%, 23%, and 48%, respectively, compared to subjects with normal hepatic function

however, its therapeutic effects eventually wear off and can even cause motor complications, such as fluctuations and dyskinesias