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In line with strong and stable interactions of His1-Ala2 of GLP-1 compared with transient interactions of His1-Gly2 in exendin-4, truncation of these two N-terminal residues reduces GLP-1 affinity by 100300 fold, whereas for exendin-4, this has no effect, albeit, for both peptides, these residues are required for GLP-1R-mediated cAMP production 22,23,24,25

The chairperson of the consensus development group guided the discussion and ensured that all the experts presented their opinions

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We stress the importance of regular follow-up appointments to monitor your progress, adjust dosages if needed, and address any concerns