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164,165,166,167 Similarly, DNA damage induces the relocalization of NAD + -dependent deacetylase SIRT1 to DNA breaks, which promotes DNA repair via opening the chromatin and recruiting the main DNA repair factors including KU70, NBS1, WRN, KAP1, XPA and APEX1

However, gonads derived from embryos generated by injection of Trim37 NLS AG-haESCs into Trim37 ko1 oocytes showed normal PGC development, possibly due to residual nuclear localization of TRIM37 (Fig

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B12 levels can become low as a result of inadequate nutrition, decreased absorption of this vitamin in the intestines, stomach problems, infections or cancer