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The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy
However, it is worth noting that GLP-1-based therapies can sometimes reduce lean muscle mass alongside fat, particularly without adequate protein intake and resistance exercise so muscle gain should not be assumed without objective body composition assessment
[12] During weight management (when bone loss typically accelerates, as discussed above), calcium supplementation suppresses elevated bone turnover and helps prevent the 1-2% BMD loss that accompanies a 10% reduction in body weight
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