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Efficacy and safety of the novel triple agonist retatrutide in type 2 diabetes. NEJM , 2023

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Miga-mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis

That single action prolongs the sense of fullness, but it is also the direct source of the characteristic gastrointestinal side effects of the GLP-1 class, from nausea to constipation