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The mediator complex: A regulatory hub for transcriptional activity of nuclear receptors

The nuclear factor of activated T cells (NFAT) is then released from the cytosol by calcineurin, allowing for the entrance of NFAT into the nucleus, where it transactivates the expression of interleukin-2 and other cytokines ( Interestingly, how cyclosporine contributes to hepatotoxicity caused by ROS is still a subject of open debate

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Martnez-Mendoza BI, Peredo-Lovillo A, Romero-Luna HE, Jimnez-Fernndez M (2023) Antioxidant and anti-inflammatory properties of yeasts fermented passion fruit and soursop pulps: a focus on bioactive volatile compounds profile