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The proportions of rapid-acting and long-acting insulins are fixed and do not allow for basal versus prandial dose adjustments
Some retrospective studies suggest CPAP treatment may reduce the risk for cardiovascular events, but other observational studies and, most importantly, randomized clinical trials have not found a significant reduction in the frequency of cardiovascular events and CVD in obstructive sleep apnea with CPAP use
A prescription is not mandatory in all regions, but many jurisdictions and healthcare providers prefer a prescription to ensure safe administration
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