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GLP-1R agonists were developed as long-acting therapeutic agents to overcome the short half-life of endogenous GLP-1, namely Semaglutide (Ozempic, Wegovy, Rybelsus)
3,507 GLP-1RAs reduce liver fat accumulation by activating AMPK, which inhibits fatty acid synthesis enzymes and promotes fatty acid -oxidation, thus diminishing lipid droplet accumulation in hepatocytes
Storage & handling Store the lyophilized vial refrigerated at 28C, protected from light and heat Reconstitute with bacteriostatic water
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