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To further support oral delivery, customized gelatin/HPMC-AS enteric capsules were engineered to provide a complementary two-tier protection strategy: (i) protecting the peptide and lipid phase from gastric enzymatic degradation and preventing premature dilution in gastric fluids that could displace the peptide from its protective lipid environment, while (ii) ensuring coordinated release of both EXE-HIP and the permeation enhancers at the intestinal absorption site

Biopsies from antrum and corpus were taken for DNA and RNA extraction

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PMID: 40225275