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They are not indicated for type 1 diabetes, should not be used with DPP-4 inhibitors, and require caution in patients with pancreatitis history or diabetic retinopathy
Long-term human data lackingpotential for unknown effects on methylation or cancer risk (NNMT linked to some tumors)
In line, Prx6 knockout mice exhibit markedly reduced levels of GPX4 and other selenoproteins, with this decrease being particularly pronounced in the brain [177] , highlighting the critical role of this redoxin in selenium metabolism and providing a missing link in selenoprotein biology that explains how cells coordinate thiol and selenium metabolism to counteract lipid peroxidation
Because theyre unregulated, their safety isnt guaranteed, and they come with a risk of skin irritation and hidden ingredients
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