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Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig
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Phase I breaks it down into metabolites, some of which are reactive and potentially harmful
Cisplatin and carboplatin, two platinum-based chemotherapeutic agents, have similar efficacy profiles, with carboplatin exhibiting reduced toxicity compared with cisplatin
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