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The largest oral trial already showed that a longer study did not guarantee a better result

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Mitochondrial dysfunction leading to oxidative stress also induces FGF21 expression in preclinical disease models ( Enhanced secretory load, imbalances in redox homeostasis, or perturbations in protein homeostasis triggered by lysosomal or autophagosomal dysfunction may all cause ER stress and trigger the unfolded protein response (UPR)

Lighter skin fades faster but is also more prone to redness and sunburn