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Shanzhiside methyl ester (SM), the major iridoid glycoside of Lamiophlomis rotata , demonstrated dose-dependent and long-lasting anti-allodynic effects in neuropathic rats without inducing tolerance [42]
Lecithin acts as a natural emulsifier, which may help dissolve fat cells in the treated area
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The paraventricular nucleus integrates these signals and coordinates downstream responses including reduced food intake
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