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According to the defined criteria for core targets selection, the top 10 core genes for osteogenic/osteoclastic process regulated by riboflavin were HIF1A, HDAC4, HDAC3, HDAC2, BCL2, TP53, MYC, NFKB1, PPARG and PPARGC1A (Figs
Ketones are transported to target organs, metabolized in the mitochondria, and converted back to acetyl-CoA for energy generation
However, discontinuation rates are similar for both treatments (approximately 6%), suggesting that while CagriSema causes more frequent gastrointestinal symptoms, they are generally manageable
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