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The results showed that after transfection with siSTAT3, GHK-Cu treatment showed a synergistic effect on the inhibition of inflammatory factors (Figures 8AE)

doi: 10.1038/s41392-023-01569-3 Summary Keywords arginine metabolism, glutamine metabolism, immunometabolism, metabolic reprogramming, therapeutic targeting, tryptophan catabolism Citation Yin Y, Yan C, Pei X, Rao J, Wu L, Xue Y, Sun H and Sheng Y (2026) Amino acid metabolism modulates macrophage polarization: implications for autoimmune-related diseases

Chugai's medicinal chemistry effort identified a series of non-peptide compounds that activated the GLP-1 receptor with nanomolar potency through a previously unrecognized binding pocket

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