activating glp-1 receptors Receptor Agonists as Treatments for Type 2 Diabetes Neurobiological Mechanisms and Therapeutic Potential

Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)

For severe deficiency, clinicians typically prescribe loading doses daily or every other day for one to two weeks followed by monthly maintenance injections

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