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Although its less common, people with vitamin B12 deficiency caused by a prolonged poor diet may be advised to stop taking the tablets once their vitamin B12 levels have returned to normal and their diet has improved

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[3] When used alone at recommended doses, phentermine has not been associated with such valvular or pulmonary complications, since it lacks direct agonism at the 5-HTB receptors implicated in fenfluramines toxicity

Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects