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Immunology 151(4):363374 Jensen AB, Srensen TI, Pedersen O, Jess T, Brunak S, Allin KH (2018) Increase in clinically recorded type 2 diabetes after colectomy
In the phase 2 NEJM 2023 trial, the net glycaemic effect of retatrutide was favourable improvements in fasting glucose and insulin resistance markers were observed suggesting that the insulin-stimulating effects of GLP-1R and GIPR agonism counterbalanced any glucose-raising tendency from glucagon receptor activation
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