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A vial stored at 15C with zero fluctuation will outperform one stored at 25C that experiences daily freeze-thaw cycles from a self-defrosting freezer

Comparison of the effect of treatment with minocycline plus budesonide combination versus minocycline plus methylprednisolone combination on the severity of already established colitis The sub-optimal doses and the route of administration for the two corticosteroids in combination with minocycline are different (budesonide = 0.5 g/kg oral gavage and methyl prednisolone = 5 mg/kg intraperitoneal injection)