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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has become one of the most prescribed medications for weight management, with studies showing an average weight loss of 1522% over one year

Though both the exposure and comparison cohorts were drawn from the same platform, which should not significantly impact the relative hazard rate ratios, results from the TriNetX platform need to be validated in other populations and platforms of EHRs