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Combating Age-Related Muscle Loss (Sarcopenia) One of the most significant challenges we face as we get older is sarcopenia, the gradual loss of muscle mass and strength
While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Esteller, 2008
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