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This is based on the observation that the livers of GCLM KO mice in all diet groups have high levels of active (phosphorylated) LKB1, a redox-sensitive kinase and the primary hepatic AMPK kinase 24

It is obvious that these approaches can provide some relief only in secondary, transient forms of TMAU, and they are completely inadequate in primary TMAU cases that need long-term therapies

Galangin significantly decreased MDA, a marker of lipid peroxidation, and increased the activities of key antioxidant enzymes, including SOD and CAT

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