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Top-line data from the CLARITY-Gastric01 study showed sonesitatug vedotin significantly extended overall survival in patients who had received at least two prior lines of therapy and also met a key secondary endpoint in an earlier-line population, although the trial failed to achieve statistical significance for progression-free survival
The breakthrough came when researchers discovered that combining glucagon receptor activation with GLP-1 activity redirects the effects toward increased calorie burning rather than hyperglycemia
Glucose loss acts as an osmotic diuretic (which is the cause for polyuria in type diabetes)
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