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Rachel Hall, Principal Doctor at Second Nature Our research at Second Nature shows that fatigue typically follows a predictable pattern: Weeks 1-4: Nearly half of patients (44%) report increased tiredness Weeks 5-8: Fatigue significantly improves, with only 22% still reporting tiredness Beyond week 12: Most patients return to normal energy levels as the body adapts For some patients, tiredness can persist longer, particularly if theyre not consuming adequate nutrition or have underlying issues like poor sleep habits or nutrient deficiencies

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N Engl J Med 387(3):205216 Mari A, Stefanski A, van Raalte DH, Ma X, LaBell ES, Fan L, Lee CJ, Thomas MK, Bunck MC, Ferrannini E (2025) Tirzepatide treatment and associated changes in -cell function and insulin sensitivity in people with obesity or overweight with prediabetes or normoglycemia: A post hoc analysis from the SURMOUNT-1 trial