A fully frozen gel pack placed directly against a vial can freeze the medication, which is equally destructive as overheating
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Klicek, R., Sever, M., Radic, B., Drmic, D., Kocman, I., Zoricic, I.,
Topical Glutathione If using glutathione-containing creams or serums (sometimes offered for localized hyperpigmentation or melasma), the timeline could be similar to other lightening topicals, expect at least 810 weeks of daily application to see improvement