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Study 4 evaluated neuronal activation in response to acute treatment with Cagrilintide or sCT in WT, RAMP1 KO, RAMP3 KO, and RAMP1/3 KO mice

furthermore, BPC 157 could significantly up-regulate the VEGF-A and VEGFR1 , paralleled by the phosphorylation of AKT , and inactivation of p38/MAPK and ERK/MAPK signaling pathways