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doi: 10.3389/fcvm.2021.723886 Received 11 June 2021 Accepted 14 October 2021 Published 23 November 2021 Volume 8 - 2021 Edited by Dianjianyi Sun, Peking University, China Reviewed by Nhat Tu Le, Houston Methodist Research Institute, United States

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Matrix metalloproteinases MMP-2 and MMP-9 accelerate degradation of basement-membrane and interstitial collagens, while tissue inhibitor of metalloproteinases-1 (TIMP-1) restrains this proteolysis

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That is not speculation

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the four components stay in their fixed manufacturing ratio

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