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As GLP-1 has been implicated as a mediator in the putative gutrenal axis (a rapid-acting feed-forward loop that regulates postprandial fluid and electrolyte homeostasis), direct actions on the kidney have been proposed
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25.2 Ephelide: note the hyperpigmentation of the basal layer of the epidermis
In line with that, a human study using the SS agonist pasireotide, with a high affinity for SSTR5, resulted in both decreased insulin and GLP-1 levels (53)
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