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Their impact is greatest in metabolically driven CKD in patients with T2D, where they complement, rather than replace, other pillars of care
10.1371/journal.pone.0016360 PLoS One 18 DixonD
These findings underscore lipid peroxide accumulation as a hallmark of ferroptosis, and suggest that downregulating ACSL4, LPCAT3, LOXs, or POR can suppress PUFA-PL-OOH formation and effectively inhibit ferroptosis
As shown above, CSOP has the potential to be a broadly useful tool for investigating diverse biological processes including protein isoform changes during cell differentiation (51), modifications in glycan height during cancer progression (26), and kinetics of protein conformation changes (52)
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