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Studies in the field of accelerated aging have established a link between PARP activation and impaired mitochondrial health, which is associated with reduced NAD + levels resulting from PARP hyperactivation 158

for example, stachyose combined with Latilactobacillus sakei repairs ICC networks by increasing 5-HT and substance P (SP) levels, inhibiting expression of VIP and NOS, with significantly greater efficacy in promoting GI peristalsis than single-agent interventions (Guo et al., 2023b)