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July 14, 2026

Unlike the previous concept, that melanomas develop de novo intra-orally, it can be hypothesized that melanomas are preceded by oral melanotic macules or melano-acanthoma, having melanocytic hyperplasia and/or dysplasia instead of having the same number of typical melanocytes with an increased tendency to synthesize melanin pigment

GABA (gamma-aminobutyric acid) inhibitor, tricyclic antidepressants, selective serotonin reuptake inhibitors and gabapentin are the most commonly prescribed drugs to reduce symptoms