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Clin Exp Rheum 41(6):1323-1331, 2023
Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-B and AP-1 activation in macrophages
Consequently, cells increase tyrosinase and other melanogenic proteins that support eumelanin production and pigment transfer to keratinocytes
As fat tissue decreases, the support structures around the bladder and urethra adjust, and this transition period can temporarily weaken continence control
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