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It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations
the FDA serotonin-syndrome warning from MAO-A inhibition (a real risk with SSRIs, SNRIs, triptans and MAOIs), G6PD haemolysis and industrial-grade purity dangers
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Jing J, Chen Y, Sheng L, Wu M
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