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GSH synthesis catalyzed sequentially by two cytosolic enzymes, -glutamyl-cysteine synthetase (GCS) and GSH synthetase is part of virtually all cell types, and the liver is the major GSH producer and exporter

On the contrary, another finding reports decrease in GPX activity in lung homogenate of rabbits exposed to simulated height of 27, 000ft for 3 h [62]

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This outcome reflects both the inherent difficulty of treating Alzheimer's disease and questions about whether a single neuroprotective mechanism, without addressing amyloid and tau pathology more directly, can be sufficient