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Combine that with people being told they can take the pill whenever means one day they might take it with food, another day on an empty stomach and that can and probably does lead to wild swings in drugs level in the blood, and if research has shown anything consistent with GLP-1 agonists it is that having big spikes and swings in drug levels tend to lead to increased side effects
Beyond small clinical cohorts, large-scale patient outcome data strongly supports the use of these compounds
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Several clinical trials have demonstrated that most of GLP-1RAs improve these parameters and thus attenuate the development and progression of atherosclerosis, especially concerning low-density lipoprotein cholesterol (LDL-C) levels [33]
