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The overall risk of clinically relevant interactions with semaglutide is therefore considered low, in the case of compounds that share the same properties as these studied drugs, including compounds with narrow therapeutic indexes
When Phase II methylation is impaired, histamine accumulates
PMID: 22254083
Another possibility is that the nausea and vomiting sometimes caused by semaglutide might lead to dehydration or an imbalance in electrolytes
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