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GIP (Glucose-Dependent Insulinotropic Polypeptide) GIP is the second major incretin hormone, secreted by intestinal K cells, with more complex metabolic effects than GLP-1: Glucose-dependent insulin secretion (similar to GLP-1) Direct effects on adipose tissue , including lipid storage and adipocyte biology Bone-metabolism effects via osteoblasts and osteoclasts Central nervous system effects modulating appetite and food reward GIP's role in metabolic research has evolved

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