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Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)
About DSIP in research Researchers use DSIP in model systems to examine peptide-mediated signalling relevant to neuronal and cellular pathways, to profile downstream assay responses, and to compare structureactivity relationshipsexclusively in controlled, non-clinical in-vitro environments
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