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Importantly, the ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10)-nicotinamide adenine dinucleotide (Phosphate) [NAD(P)H] and tetrahydrobiopterin (BH4)-dihydrofolate reductase (DHFR) pathways, though functioning independently, complement each other and, alongside GPX4 and glutathione, play crucial roles in preventing phospholipid peroxidation and, consequently, ferroptosis [114,115,116]
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One reason may be its role as a cofactor of glutathione peroxidase
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