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Cagrilintide + Tirzepatide Storage & Handling Storage Reference (Both Compounds) State Lyophilized (long-term) Tirzepatide -4 F (-20 C), 12+ months Cagrilintide -4 F (-20 C), 12+ months State Lyophilized (short-term) Tirzepatide 35.6-46.4 F (2-8 C), several months Cagrilintide 35.6-46.4 F (2-8 C), several months State Reconstituted (liquid) Tirzepatide 35.6-46.4 F (2-8 C), 28-30 days Cagrilintide 35.6-46.4 F (2-8 C), 28-30 days State Color when reconstituted Tirzepatide Clear, colorless Cagrilintide Clear, colorless State Shake

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The GPx activity was calibrated using a reference method (Rotruck et al

Differences in reconstitution, storage, and administration technique can affect both the compound's effectiveness and its side effect profile