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Chinese and international studies have confirmed these effects of metformin through experimental methods and explored the related molecular mechanisms in depth ( Figure 2 )

Glutathione can bind to various minerals as part of its transport and detox roles

A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule (Hammes et al., 2011), and possibly invoke effects of the adjacent subunit of the dimeric enzyme for a deeper insight into structural requirements for the isomerization mechanism

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