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The useful analytical framework is to ask: what is the net present value of revenues the innovator can defend after patent expiry, given realistic lifecycle management success rates, biosimilar/generic competition timelines, and payer formulary dynamics
Ashrafnezhad Z, Naji M, Aleyasin A, Hedayatpour A, Mahdavinezhad F, Gharaei R, Qasemi M, Amidi F
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