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Consequently, AgNP-mediated inhibition of protein phosphorylation disrupts enzymatic activity, ultimately hindering bacterial growth and survival ( 5.5 Induction of apoptotic-like cell death In addition to oxidative stress and metabolic disruption, AgNPs can trigger apoptosis-like responses in bacteria

Preclinical studies have shown that PD-1/PD-L1 blockade can mobilize monocyte-derived macrophages, enabling their infiltration into the brain to reduce pathology and combat cognitive decline in 5XFAD AD mice [350, 351]

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