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This rapid and sustained effect is biologically plausible, as GLP-1 receptors are expressed in key central nervous system areas implicated in reward, motivation, stress, and addiction.20 At clinically therapeutic doses, GLP-1 receptor agonists cross the blood-brain barrier and are thought to modulate dopamine neurotransmission in the mesolimbic system, reducing the rewarding properties of addictive drugs.314202168697071 Other potential mechanisms include the potentiation of inhibitory -aminobutyric acid-ergic tone,72 modulation of the hypothalamic-pituitary-axis, serotonin, and glutamate systems,18192021 and indirect neuroprotective and anti-inflammatory effects that could mitigate the chronic neurobiological consequences of SUDs.62 Limitations and strengths of this study This study has several limitations
On the other hand, if constipation is an issue, increasing your fiber intake and staying hydrated should provide relief
Given that there are no major, obvious differences in tolerability, efficacy on glycemic parameters, weight loss, or overt advantages regarding administration, it is likely that the use of LIXI in place of other GLP-1 agonists will be based on cost (79)
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